Immutep (ASX:IMM) has entered a clinical trial collaboration and supply agreement to evaluate the combination of its lead immunotherapy product candidate, eftilagimod alpha ('efti' or 'IMP321'), with MSD's anti-PD-1 therapy KEYTRUDA (pembrolizumab) in a new clinical trial that will evaluate the combination in several different solid tumours.
The planned phase 2 clinical trial, referred to as TACTI-002 (Two ACTive Immunotherapies), will evaluate the safety and efficacy the combination in patients with non-small cell lung cancer (NSCLC), head and neck cancer, or ovarian cancer.
Up to 120 patients across the three indications are planned to be treated in medical centres in Europe and the US with the trial expected to commence in the second half of 2018.
“We are extremely pleased to be collaborating with MSD, one of the world’s leading immuno-oncology companies,” said Marc Voigt, CEO of Immutep.
“This clinical trial will evaluate a novel combination of two complementary immuno-oncology treatments in three cancer indications simultaneously, which could lead to more rapid drug development subject to successful outcomes.
"The data generated thus far from our ongoing TACTI-mel clinical trial has supported our hypothesis that there is a compelling therapeutic synergy in administering efti in combination with another immuno-oncology treatment. This new Phase II clinical trial significantly builds on the momentum we are delivering in the evaluation of efti in cancer, with two Phase I clinical trials and now two Phase II clinical trials in our program for 2018.”
Immutep’s 'efti' is a first-in-class antigen presenting cell activator that stimulates cancer-fighting T cells, while KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body’s immune system to help detect and fight tumor cells.